Subgroups characterized by psychological trauma, mental comorbidity, and psychobiological patterns and their specialized treatment

Project leader: Prof Dr. Wolfgang Eich

Summary:
Musculoskeletal pain is the main cause of chronic long-term pain and disability. About of the population suffers from chronic musculoskeletal pain in there life. Although knowledge of incidence and prevalence as well as sociodemografic and mental correlates is well established, therapeutic interventions in musculoskeletal pain are often of minor success. This is probably due to the fact that etiology and pathogenesis of musculoskeletal pain are still widely unknown, resulting in predominantly unspecific interventions.

Subproject six (Subgroups characterized by psychological trauma, mental comorbidity, and psychobiological patterns and their specialized treatment) of the consortium LOGIN targets at mental comorbidity (anxiety, depression) of chronic musculoskeletal pain and psychophysiological and neurobiological correlates. Thereby, one main aspect is the role of experienced psychiatric trauma in chronic musculoskeletal pain, because this relationship seems to be of special interest.

Aims of subproject six:

  • Determine prevalence of chronic musculoskeletal pain and mental comorbidity in a populations-based sample and a tertiary care sample.
  • Describe subgroups with different somatosensory profiles measured with quantitative sensory testing (QST) und evaluation of excitatory and inhibitory descending pain modulating systems (DNIC).
  • Measurement of nerve growth factor (NGF) and endocannabinoids.
  • Treatment of chronic musculoskeletal pain patients with experienced mental trauma with a trauma-focused short-time intervention (pilot study).  
  • Development of a mechanisms-based subgroup classification of musculoskeletal pain patients.


In a second funding period specific mechanism-based therapeutic interventions will be developed.