Subprojects

The consortium consists of seven subprojects with different research aspects:

Prof. Dr. Siegfried Mense (Mannheim, subproject 1):
Öffnet internen Link im aktuellen FensterIn this subproject psychoneurobiological mechanisms will be studied that are assumed to be involved in the transition from local to chronic widespread musculoskeletal pain. As models of musculoskeletal pain, rats will be used in which acute or chronic low-back pain has been induced.


Prof. Dr. Beat Lutz (Mainz, subproject 2):
Öffnet internen Link im aktuellen FensterThis subproject aims at substantiating the hypothesis of a strong relation between anxiety disorders, such as depression and posttraumatic stress disorder (PTSD), with the emergence of increased pain sensitivity, and a transition from local to chronic widespread pain.


Prof. Dr. Martin Schmelz
(Mannheim, subproject 3):
In this subproject the differential role of NGF in inducing sensitization in muscle and skin will be investigated. Moreover, by local injections in the skin, muscle fascia, and muscle we will identify the tissue most sensitive to NGF and thereby verify target structures for future analgesic therapy.


Prof. Dr. Rolf-Detlef Treede (Mannheim, subproject 4):
Öffnet internen Link im aktuellen FensterThe aim of this subproject is to study the differential susceptibility of subcutis, fascia and muscle for acute nociceptive sensitivity and short-term sensitization, and changes thereof in acute musculoskeletal back pain, chronic local or widespread musculoskeletal pain.


Prof. Dr. Herta Flor (Mannheim, subproject 5):
Öffnet internen Link im aktuellen FensterIn this subproject we will examine to what extent enhanced central sensitization and deficient descending inhibition as assessed by stress analgesia are core characteristics of widespread musculoskeletal pain and how they differ in localized pain.


Prof. Dr. Wolfgang Eich (Heidelberg, subproject 6):
Öffnet internen Link im aktuellen FensterThis subproject aims to identify psychophysiological and neurobiological correlates of musculoskeletal pain and mental co-morbidity (especially mental trauma).


Prof. Dr. Annette Becker (Marburg, subproject 7):
Öffnet internen Link im aktuellen FensterThis subproject studies the prevalence of localized and chronic widespread pain in primary care. Moreover, predictors for the generalization and the persistence of chronic local pain in low-back pain patients will be identified.